Sonia Lucena, psychonutritionist, on Kyoto protein: "Science is advancing rapidly, and its application to longevity is booming."

In the field of longevity, one of the molecules that has attracted the most attention recently is the so-called Kyoto protein , the popular name given to the Klotho protein . This substance was discovered in 1997 at Kyoto University by Dr. Makoto Kuro-o, and since then it has been investigated for its role in slowing down aging . Psychonutritionist Sonia Lucena , a specialist in sports nutrition, sums it up clearly: “ Science is advancing rapidly and the science applied to longevity is booming ,” a statement that reflects the growing interest in interventions that help people live longer and better .

Early studies in mice showed that the absence of Klotho led to premature aging , while overexpression of Klotho prolonged lifespan by 20–30%. In humans, several studies have shown that low levels of this protein in the blood are associated with a higher risk of mortality , even in the absence of diseases such as diabetes or hypertension. Research led by Dr. Dubal also revealed that increased Klotho production in animals improved mental functions such as memory and thinking speed , which tend to deteriorate with age, especially in men.

A biological profile with key protective functions

The Klotho protein acts as an antioxidant , reducing the formation of free radicals by inhibiting the insulin receptor pathway. It also has anti-inflammatory effects by modulating the activity of NF-κB, a component involved in chronic low-grade inflammation. Furthermore, its role in vascular and renal protection makes it a fundamental piece for healthy aging . In men, its influence on muscle and bone mass may contribute to the maintenance of testosterone and prevent the onset of fragile man syndrome , common after the age of 60.

Currently, there are no Klotho supplements available on the market, but various studies suggest that certain practices help maintain its production at adequate levels. Sleeping well , practicing strength training , maintaining optimal vitamin D levels, and controlling sugar consumption are factors that could have a positive influence. Based on her experience, Sonia Lucena insists that the future of preventive medicine lies in integrating these advances into daily life. The Kyoto protein is not an empty promise, but a real path that, if confirmed, will not only extend life but also improve its quality .